Centrient Pharmaceuticals boosting statins API manufacturing capacity

Rotterdam, The Netherlands, June 21, 2021 (GLOBE NEWSWIRE) —

Summary:

  • Centrient Pharmaceuticals has started production at its newly built statins API manufacturing unit in Toansa, India.
  • With this expansion the company is doubling its production capacity of Atorvastatin and Rosuvastatin, meeting the increased demand for its high-quality uniquely produced statins.
  • Centrient Pharmaceuticals’ statins are one of the most sustainably produced in the industry by eliminating harmful solvents, generating less waste, and a reduced carbon footprint of 32% as compared to traditional manufacturers.
  • Using backward integrated manufacturing methods, and dedicated production facilities, Centrient Pharmaceuticals is able to offer its customers security of supply.

Centrient Pharmaceuticals (“Centrient”), the global leader in sustainable antibiotics, next-generation statins and anti-fungals, announced today to have started production at its new statins manufacturing unit. With the building of its second dedicated unit on the Toansa site in India now completed, the company will double its statins production capacity. This will enable Centrient to meet growing demand for its sustainably manufactured Atorvastatin and Rosuvastatin Active Pharmaceutical Ingredients (APIs).

Statins are currently the most prescribed drug class globally for the treatment of high cholesterol and cardiovascular diseases and are among the top-selling drugs worldwide. The markets for Atorvastatin and Rosuvastatin in particular, has shown steady growth in the past years, as a result of the continued global prevalence of high cholesterol issues, replacement of older generation statins, and genericization of the market.

Starting almost a decade ago, Centrient has grown today into one of the leading statin API suppliers worldwide, servicing large pharma companies around the globe.

Next to high-quality features like long shelf life and large batch sizes, the company offers security of supply to customers through its dedicated statins production facility and backward integration. Being backward integrated, Centrient is independent from external imports of starting materials. Its enzymatic route of synthesis and patented technology minimise the use of harmful solvents, generate less waste, and reduce the company’s carbon footprint by 32% as compared to traditional manufacturers.

The news of the facility expansion follows major milestones on statins that the company reached in the past years. In 2012, under the name of DSM Sinochem Pharmaceuticals, it was the first pharmaceutical manufacturer worldwide to offer generic Atorvastatin APIs under a Certificate of Suitability to the Monograph of the European Pharmacopoeia (CEP). Since 2014, it has produced the unique Atorvastatin APIs in its state-of-the-art facility in Toansa, India for third-party customers.

In addition, the company was one of the first three companies worldwide that started to offer generic Rosuvastatin APIs under CEP in 2016. Two years later, the first generic Rosuvastatin and Atorvastatin finished dosage forms were launched in Western Europe.

“With the doubling of our production capacity, we demonstrate our commitment to maintain our leadership position in line with our strategy and to continue supporting our customers’ business growth. Guided by our brand promise of Quality, Reliability, and Sustainability, Centrient’s Rosuvastatin and Atorvastatin offer superior performance in all three areas to the benefit of our customers and the environment.”, says Frans Vlaar, Chief Commercial Officer at Centrient.

Ground breaking of the new manufacturing unit started at the end of 2019 and commercial supplies from the new unit will start in mid-2021With the new manufacturing line being operational and doubling the production capacity, Centrient will be even better positioned to secure supply, meeting the growing demand from customers and helping to improve the lives of patients who are in need of these medicine.

“We are extremely proud that we have been able to complete this project in a timely way given the challenges of executing such a complex project in the midst of the COVID pandemic,” says Jim McPherson, Chief Quality & Technical Operations Officer. “It reinforces our absolute commitment to meet the expectations of our customers as a partner of choice – delivering reliable and secure supply using leading sustainable technologies. The facility incorporates design features that allow further improvements in GMP and energy utilization, and enable greater automation for improved process control.”

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About Centrient Pharmaceuticals

Centrient Pharmaceuticals is the leading manufacturer of beta-lactam antibiotics, and a provider of next generation statins and antifungals. We produce and sell intermediates, active pharmaceutical ingredients and finished dosage forms.

We stand proudly at the centre of modern healthcare, as a maker of essential and life-saving medicines. With our commitment to Quality, Reliability and Sustainability at the heart of everything we do, our over 2200 employees work continuously to meet our customers’ needs. We work towards a sustainable future by actively participating in the fight against antimicrobial resistance.

Founded 150 years ago as the ‘Nederlandsche Gist- en Spiritusfabriek’, our company was known as Gist Brocades and more recently DSM Sinochem Pharmaceuticals. Headquartered in Rotterdam (Netherlands), we have production facilities and sales offices in China, India, the Netherlands, Spain, Egypt, the United States and Mexico. Centrient Pharmaceuticals is wholly owned by Bain Capital Private Equity, a leading global private investment firm.

For more information please visit www.centrient.com or contact Centrient Pharmaceuticals Corporate Communications, Alice Beijersbergen, Director Branding & Communications. E-Mail: alice.beijersbergen@centrient.com.

Forward-looking statements
This press release may contain forward-looking statements with respect to Centrient Pharmaceuticals’ future financial performance and position. Such statements are based on current expectations, estimates and projections of Centrient and information currently available to the company. Centrient cautions readers that such statements involve certain risks and uncertainties that are difficult to predict and therefore it should be understood that many factors can cause actual performance and position to differ materially from these statements. Centrient has no obligation to update the statements contained in this press release, unless required by law. The English language version of the press release is governing.

Alice Beijersbergen
Centrient Pharmaceuticals
alice.beijersbergen@centrient.com

JinkoSolar delivers initial DC-coupled storage system to West Africa

SHANGHAI, June 21, 2021 /PRNewswire/ — JinkoSolar Holding Co., Ltd. (the “Company” or “JinkoSolar”) (NYSE: JKS), one the largest and most innovative solar module manufacturers, today announced to deliver 1.2MWh of energy storage system to West Africa. JinkoSolar’s experience in solar, storage, complex multi-application systems resulted in offering a new solution in African market: integrating batteries, Power Conditioning System (PCS), DC modular, switch cabinets, with EMS software. This all-in-one, fully integrated modular and compact solution minimizes complexity of deployment activities, and delivers the lowest lifecycle costs.

JinkoSolar Energy Storage Project in West Africa

JinkoSolar’s DC coupled battery storage system can meet project requirements of varying scale and is suitable for various environmental conditions, making it an ideal solution for grid ancillary services and C&I applications while ensuring reliability and safety. The potential advantage of this DC coupled solution Includes improved system efficiency, lower balance of plant costs, and clipped solar recapture. With storage attached to the solar system, the batteries can be charged with excess solar generation when the PV reaches its peak and would otherwise begin clipping. The stored energy can be introduced into the grid at the appropriate time, maximizing the value of the system’s generation. The flexibility and broad capabilities of the EMS software enable effective and efficient control and management over the entire system, compatible with solar, wind, grid, and diesel engines.

“For us, this is a milestone project of delivering ESS system to Africa.  It is one of our initial storage projects globally on this scale using DC-coupling. Africa is a very promising market for energy storage due to relatively poor state grid infrastructure and high electricity price, there is a strong potential to replace peaker gas or cola fired plants in Africa with cleaner alternatives like solar made dispatchable using batteries,” said Gener Miao, CMO of Jinkosolar.

Photo – https://mma.prnewswire.com/media/1537317/Africa_Energy_Storage.jpg

UN Refugee Chief Encouraged by Changes in US Resettlement Program

U.N. High Commissioner for Refugees Filippo Grandi says the asylum system in the United States has become “unmanageable” and that his agency supports “a gradual improvement towards a more effective and humane migration system.”

In an interview with VOA, Grandi said such reform is a complex operation that will take years to achieve, but that he is encouraged by what he has seen from the Biden administration after a big cut in resettlements during the Trump administration.

“We support that because that is the indispensable piece in a broader exercise to handle human mobility in Central America, which includes the movement of people that are refugees because they flee from violence, from persecution, from discrimination,” he said. “That work has to be done at every level, has to be done in the countries of origin — mostly Honduras, El Salvador, to an extent Guatemala — has to be done in the countries of transit, including Guatemala itself and Mexico, and has to be done at the border.”

The maximum number of refugees allowed into the United States fell from 85,000 in 2016 to 18,000 in 2020. The Biden administration has boosted the cap to 62,500 refugee admissions this year, with plans to boost it further to 125,000.

Grandi said in addition to the decline in U.S. capacity, the coronavirus pandemic also helped to drastically affect refugee resettlement throughout the world during 2020. He said the total number of resettlements fell from about 100,000 in 2019 to 34,000 last year.

“We had to suspend resettlement travel simply because there were no more flights,” he told VOA. “We couldn’t use the routes because they were not operating. These are realities that are now being slowly overcome, but it will take some time.”

Grandi said the coronavirus pandemic has made it clear that countries “can’t cope alone” and that governments sometimes need help explaining to their citizens the value of programs to help refugees.

“They need international support, especially when they embark on policies that may be difficult, even controversial, for their own domestic audiences,” Grandi said. “International support helps explain to their populations the importance of these very good policies.”

He highlighted progress in Colombia, which in February announced 10-year protective status for 1.7 million displaced Venezuelans.

“Already more than one million Venezuelans have entered the first phase of the registration. This is amazing,” Grandi said. “And also, in a situation in which Colombia itself has difficult challenges — the pandemic, the social and political unrest, residual displacement from the conflict, the peace process. So, in the middle of all this, I think that for Colombia to embrace a very forward-looking inclusive refugee and migration policy is very important.”

However, Grandi said Colombia’s action represents “one of the bright spots in this very negative picture.”

He cited the continuing challenge of spike in the number of people being forced to leave their homes, a number that rose by 3 million people last year to reach 82.4 million at the end of 2020, according to the U.N. Refugee Agency UNHCR.

“It means that wars, discrimination, bad governance, often combined with other factors like climate change, inequality and poverty, demographic imbalances, all of this has not stopped human mobility, especially the forced aspects of human mobility,” Grandi said. “The secretary general issued many calls for a global cease-fire. Frankly, it was not really heeded.”

Despite the ongoing challenges, when asked what message he has for refugees, Grandi said, “Don’t lose courage.”

“We draw ourselves encouragement from your resilience. Don’t give up and we will be there with you to help you move on,” he said.

Source: Voice of America

Ethiopian Polls Extended as Crowds Wait to Vote

When the polls were supposed to close Monday in the Ethiopian capital of Addis Ababa, election workers said turnout was better than expected, and voting had been conducted safely. 

But crowds of people still queued, and closing time was extended for hours. Election organizers said logistical problems such as missing poll workers or ballots and bad weather were to blame.

Many people waited all day to cast their ballot in Ethiopian Prime Minister Abiy Ahmed’s first electoral contest. The vote is widely expected to solidify his rule, despite the beleaguered Tigray region’s nonparticipation and the postponement of several other regions’ votes for security reasons.

“This is, maybe not the last, but a very important chance to transform to democracy,” said Yeshiwas Assefa, chair of Ethiopian Citizens for Social Justice, the main opposition party.

The ruling Prosperity Party is widely expected to win the election, but Assefa said the new parliament could be the most diverse in Ethiopian history, with opposition candidates expected to win some seats.

But his office counted more than 200 election irregularity complaints Monday, ranging from missing ballots to observers being intimidated at the polls.

Eden Hagos, a 27-year-old receptionist, arrived at the polls at 3 a.m. to line up to vote. By 6 p.m., she was exhausted and hungry, and unsure how much longer she could wait.

“It was supposed to be my first time voting, and I was so excited,” she said, in a crowded, wet garden where hundreds of people still queued Monday evening. “But now, I’m angry.”

Ruling party support

As the sun went down, some other voters said they would wait as long as it took.

Ayalew Gebremichael, a 43-year-old fitness instructor, said in previous elections, opposition parties were repressed, and voters were pressured.

“This is different,” he said as the line snaked around a building. “It is more free and fair than the others.”

Up a small hill and closer to the ballot boxes, Masho Ayele, 27, and a mother of two, wore a black coronavirus face mask and a pink knit hat. She had been at the polls since 6 a.m. to vote but said she planned to wait all night if necessary.

“In my opinion,” she said, “this election is going to change my life.”

Ayele said she supports the prime minister and believes the country is already getting stronger under his rule. The election itself, she said, is evidence the country is growing more free, with poll workers telling voters to choose as they wish.

“In the past elections, they told me who to vote for, and I was scared,” she explained. “I did what they said.”

Conflict in Tigray

But there will be no voting at all in Ethiopia’s northern region of Tigray, which has been at war with the federal government for more than seven months.

The conflict has killed thousands of people and displaced roughly 2 million. Civilians across the region have reported human rights abuses, like mass killings and rapes. The United Nations says 350,000 people are in danger of starving in a famine that is already under way.

At a traditional coffee shop in Addis Ababa, Habenyom Mekonen, a businessman from Tigray, said as a long-term resident, he can vote in the capital, but he refused to register.

“There is no party that represents us,” he explained.

The Tigray People’s Liberation Front (TPLF) won local elections in Tigray last year in a ballot the federal government said was illegal. Then, after tensions deepened and war broke out, the government declared the TPLF a terrorist organization, making members ineligible to run, even if there was an election in Tigray.

Several other areas are postponing their votes until September, also because of conflicts, and in some cases, missing ballots.

Also missing are European Union observers who declined to attend after being denied permits to use their equipment in Ethiopia.

Analysts say if this election does, in fact, produce a more diverse government, achieving an enduring pluralistic democracy will take time.

“There are politicians who really believe in the electoral process,” said Kiya Tsegaye, a lawyer and political analyst. “There are also politicians who believe they can cling to power through shortcuts.”

Source: Voice of America

Somalia, Congo, Afghanistan, Syria Among Most Dangerous for Children in Conflict

Somalia, Congo, Afghanistan and Syria top the list of the most dangerous conflict zones for children, the United Nations said Monday, accounting for nearly 60% of all violations among the entries on its annual blacklist of countries where children suffer grave abuses.

“Children can no longer be the last priority of the international agenda nor the least protected group of individuals on the planet,” Virginia Gamba, U.N. special representative for children in armed conflict, told reporters Monday at the report’s launch. “We need to give children an alternative to violence and abuse. We need peace, respect for children’s rights, and democracy.”

Gamba said the most widespread violations in 2020 were the recruitment and use of children by security forces and armed groups and the killing and maiming of children.

“We are extremely alarmed at the increase in the abduction of children by 90% compared to previous years, as well as the increase in rape and other forms of sexual violence, registering an increase of 70% compared to previous years,” she added.

More than 3,200 children were confirmed abducted in conflict situations in 2020, and at least 1,268 were victims of sexual violence, the report said.

Of the worst offenders, Gamba said Somalia had the “most violations by far,” primarily perpetrated by al-Shabab terrorists. In Afghanistan, she said the Taliban was responsible for two-thirds of violations, and the government and pro-government militias the rest.

Myanmar also ranked high on the list of grave violations, including for the highest numbers of children recruited and used, while Yemen has among the highest figures for children killed or maimed.

Attacks on schools and hospitals remained high last year at 856, mostly in Afghanistan, Congo, Syria and Burkina Faso.

“Education against girls was particularly targeted,” Gamba said.

As with everything else in 2020, the COVID-19 pandemic only complicated matters.

The report found, for example, that the use of schools by militaries rose last year. Many schools were closed temporarily because of the pandemic, making them easy targets for military occupation and use.

New to the list are Cameroon, Burkina Faso and the Lake Chad Basin region.

The report contained some good news. Due to advocacy efforts, armed groups and security forces released 12,643 children. And the number of actors engaging with Gamba’s office, signing on to action plans and making new commitments toward children is growing.

However, human rights groups have criticized the report over the years, saying that double standards apply to the creation of the blacklist and that some countries escape accountability.

“We strongly urge the (U.N.) Secretary-General to reconsider his decision and hold parties to conflict all over the world to the same standard,” Inger Ashing, CEO of Save the Children International, said in a statement.

“Secretary-General (Antonio) Guterres is letting warring parties implicated in the deaths and maiming of children off the hook by leaving Israel, the Saudi-led coalition (in Yemen) and other violators off his ‘list of shame,'” said Jo Becker, children’s rights advocacy director at Human Rights Watch. “His repeated failure to base his list on the U.N.’s own evidence betrays children and fuels impunity.”

Responding to the criticism, Gamba said that regarding Israel, violations carried out during the recent fighting in Gaza would be examined in next year’s report.

She added that she did not experience any political pressure from parties in terms of who would be listed.

Source: Voice of America

Nearly 6,000 Displaced Return Home After Niger Jihadist Attacks

Nearly 6,000 people who fled jihadist violence in 2015 have returned home to the town of Baroua in southeast Niger’s troubled Diffa region, local authorities said Monday.

They are the first group to go home as part of a operation to return people to 19 towns and villages in the region, which has been ravaged by jihadists from neighboring Nigeria.

“It is a voluntary return of 1,187 households totaling 5,935 people” who returned on Sunday to Baroua, a town of some 15,000 near Lake Chad, said Yahaya Godi, a top official in the Diffa region.

Between 8,000 and 10,000 people are expected to return to Baroua in total.

State television showed images of around 20 trucks loaded with food, water, beds and building materials, with the returnees perched on top, arriving in Baroua.

Diffa is home to 300,000 refugees and internally displaced people (IDPs) who have fled attacks by the Nigeria-based jihadist group Boko Haram and its breakaway faction Islamic State West Africa Province (ISWAP), according to the UN.

Niger’s government gave the go-ahead for the return of IDPs “given positive changes in the (security) situation on the ground,” said Diffa regional governor Issa Lemine, who was in Baroua to welcome the returnees.

Niger’s security forces are working to ramp up protection for returning residents, he added.

Most of the IDPs had fled to other parts of the region, notably the city of Diffa itself.

Some 120,000 refugees from jihadist attacks in northeastern Nigeria are housed in camps around the Diffa region.

ISWAP has become a dominant threat in Nigeria, attacking soldiers and bases while killing and kidnapping civilians.

Baroua “is in ruins and we will have to start from scratch,” a local elected official told AFP.

Health clinics, drinking water distribution facilities, schools and mosques are “all run down”, he added.

Godi said people who are still reluctant to return will be encouraged by the stepped-up security as well as rebuilt infrastructure.

And the government will hire returnees to work on rebuilding projects in Baroua.

Niger’s President Mohamed Bazoum, elected in February, campaigned on a promise to return all refugees and displaced people to their homes by the end of 2021.

The former French colony, which by the yardstick of the UN’s Human Development Index is the poorest country in the world, also houses nearly 60,000 people who fled after the jihadist insurgency erupted in neighboring Mali in 2012.

Source: Voice of America

World Bank Says Zimbabwe’s Economy on Recovery Path

In a report this month, the World Bank predicts Zimbabwe’s economy will grow 3.9% this year even as the country sees an alarming rise in poverty levels, especially in urban areas. The report says a record 7.9 million Zimbabweans are “extremely” poor, earning less than 30 U.S. dollars a month.

Forty-one-year-old Richard Luzani is one of many unemployed Zimbabweans hoping the economy will recover and that the coronavirus pandemic will end soon.

Each day he pushes a cart full of water buckets while selling the scarce precious liquid in Hatcliffe — one of the poorest suburbs of Harare. He works with his 58-year-old father, Weluzani.

“I wish I could a get any formal job,” Luzani said. “I am just barely making a living from this hustle of selling water so that my family can survive. But so far everything is down.”

He said on a good day they go home with $5 each — but other days, nothing.

That is not case with 40-year-old Tafadzwa Gamanya in Goromonzi, a rural area about 50 kilometers east of Harare.

A World Bank report says Zimbabweans living in rural areas are doing better than their counterparts in the urban areas thanks to subsistence farming. So is Gamanya.

“This year is much better for us here. We had good rains. We have enough water to irrigate our crops until the next rain season,” Gamanya said. “I have maize and sweet potatoes; my peas are at flowering stage. I sell my vegetables to get money for sugar, for tea which we have with sweet potatoes. Our maize is enough for this year. We have nothing more to ask or cry for.”

Last week, President Emmerson Mnangagwa’s government said the number of food insecure Zimbabweans has drastically fallen because of the good rains the country has enjoyed during the 2020/2021 agriculture season.

Mukami Kariuki, who heads the World Bank in Zimbabwe, says the economy could recover faster depending on how the pandemic and regional economy perform.

“Zimbabwe’s economy is expected to grow faster than its neighbors, rising from 3.9% in 2021 to 5.1% in 2022,” Kariuki said. “By comparison, the average growth rate for sub-Saharan Africa in 2021 is 2.8%. So overall, we note that the recovery of the country is on a positive trend and if sustained, this momentum will impact positively on the lives and livelihoods of people of Zimbabwe.”

An upward swing would be welcome news for Richard Luzani and millions of Zimbabweans like him. The World Bank reports 49% of the country’s population now live in poverty due to both the pandemic and ailing economy.

Source: Voice of America