Taconic Biosciences Launches First and Only Super Immunodeficient Mouse Models Lacking Residual Murine Fc Gamma Receptors, for Improved Antibody Therapy Assessment

FcResolv™ NOG Models Provide Greater Clarity and More Translatable Data

RENSSELAER, N.Y., Oct. 24, 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, has launched the FcResolv™ NOG portfolio, the first and only super immunodeficient mouse models lacking residual murine Fc gamma receptors (FcγRs) known to confound results in antibody-based therapy studies.

Murine FcγRs can cause false positives or false negatives, leading to incorrect conclusions and derail drug discovery. FcResolv NOG models knock out these receptors for greater clarity in antibody-based drug studies, affording investigators greater confidence and more translatable data with fewer studies and fewer animals. With applicability in oncology, immuno-oncology, and autoimmune disease, FcResolv NOG models are suitable for engrafting a wide range of human cells and tissues, including simultaneous human tumor engraftment and immune system humanization.

“Antibody-based therapies represent one of the fastest-growing classes of drugs, creating a pressing need for better preclinical tools to assess therapeutics such as monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies,” said Dr. Michael Seiler, vice president of commercial products at Taconic. “Taconic’s FcResolv NOG portfolio enables researchers to evaluate drug candidates like these on their own merits, free of interference from residual murine Fc gamma receptor activity.”

FcResolv NOG models eliminate the false negatives that occur when an antibody-based therapeutic’s Fc domain interacts with murine FcγRs as well as the false positives that result when FcγRs trigger residual murine immune activity. They also eliminate costly deconvolution steps otherwise needed to distinguish true drug efficacy from off-target effects mediated through the mouse immune system. With more reliable answers, researchers can target their drug discovery investments more strategically and effectively.

The FcResolv NOG model portfolio is based on the super immunodeficient CIEA NOG mouse®. The portfolio currently includes two models:

  • FcResolv NOG, for tumor xenografts using cell lines or patient-derived tumors, engraftment of other normal or pathological human cells and tissues, and immune system humanization studies
  • FcResolv hIL-15 NOG, which supports engraftment of human NK cells and is suitable for efficacy studies on antibody-based therapeutics with an antibody-dependent cellular cytotoxicity (ADCC) mechanism of action

To learn more about the FcResolv NOG portfolio, visit www.Taconic.com/fcresolv. Or call 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates service laboratories and breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:

Louise Baskin, Senior Director New Product Pipeline

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670208

Taconic Biosciences lance le premier et le seul modèle de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels, pour une évaluation améliorée de la thérapie par anticorps

Les modèles FcResolv™ NOG offrent une plus grande clarté et des données plus traduisibles

RENSSELAER, New York, 24 oct. 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, un leader mondial dans la fourniture de solutions de modèles animaux pour la découverte de médicaments, a lancé le portefeuille FcResolv™ NOG, les premiers et seuls modèles de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels (FcyRs) connus pour fausser les résultats dans les études thérapeutiques à base d’anticorps.

Les FcyRs murins peuvent provoquer de faux positifs ou de faux négatifs, ce qui conduit à des conclusions erronées et fait dérailler la découverte de médicaments. Les modèles FcResolv NOG éliminent ces récepteurs pour une plus grande clarté dans les études médicamenteuses à base d’anticorps, offrant aux chercheurs une plus grande confiance et des données plus traduisibles avec moins d’études et moins d’animaux. Avec une applicabilité en oncologie, en immuno-oncologie et en maladie auto-immune, les modèles FcResolv NOG sont adaptés à la greffe d’un large éventail de cellules et tissus humains, y compris la greffe de tumeurs humaines simultanée et l’humanisation du système immunitaire.

« Les thérapies à base d’anticorps représentent l’une des classes de médicaments à la croissance la plus rapide, créant un besoin urgent de meilleurs outils précliniques pour évaluer des traitements tels que les anticorps monoclonaux, les conjugués anticorps-médicaments et les anticorps bispécifiques », a déclaré le Dr Michael Seiler, vice-président des produits commerciaux chez Taconic. « Le portefeuille de récepteurs FcResolv NOG de Taconic permet aux chercheurs d’évaluer des médicaments candidats tels que ceux-ci selon leurs propres mérites, sans interférence de l’activité résiduelle du récepteur Fc Gamma murin. »

Les modèles FcResolv NOG éliminent les faux négatifs qui se produisent lorsqu’un domaine Fc thérapeutique à base d’anticorps interagit avec les FcyRs murins, ainsi que les faux positifs qui en résultent lorsque les FcyRs déclenchent une activité immunitaire murine résiduelle. Ils éliminent également les étapes de déconvolution coûteuses nécessaires pour distinguer une véritable efficacité médicamenteuse des effets hors cible induits par le système immunitaire de la souris. Grâce à des réponses plus fiables, les chercheurs peuvent cibler leurs investissements dans la découverte de médicaments de manière plus stratégique et plus efficace.

Le portefeuille de modèles NOG FcResolv est basé sur la souris® NOG CIEA super immunodéficiente. Le portefeuille comprend actuellement deux modèles :

  • FcResolv NOG, pour les xérogreffes tumorales utilisant des lignées cellulaires ou des tumeurs dérivées des patients, la greffe d’autres cellules et tissus humains normaux ou pathologiques, et les études d’humanisation du système immunitaire
  • FcResolv hIL-15 NOG, qui supporte la greffe des cellules NK humaines et convient pour des études d’efficacité sur les thérapies à base d’anticorps avec un mécanisme d’action de cytotoxicité cellulaire dépendant des anticorps (ADCC)

Pour en savoir plus sur le portefeuille de FcResolv NOG, rendez-vous sur www.Taconic.com/fcresolv. Vous pouvez également appeler le 1-888-TACONIC (888-822-6642) aux États-Unis, le +45 70 23 04 05 en Europe, ou envoyer un e-mail à l’adresse info@taconic.com.

À propos de Taconic Biosciences, Inc.

Taconic Biosciences est un leader mondial pleinement agréé dans les modèles et les services de rongeurs génétiquement modifiés. Fondée en 1952, Taconic offre les meilleures solutions animales afin que les clients puissent acquérir, générer d’une manière personnalisée, élever, pré-conditionner, tester et distribuer des modèles de recherche précieux dans le monde entier. Spécialiste des modèles de souris et de rats génétiquement modifiés, du microbiome, des modèles de souris pour l’immuno-oncologie et des services de conception de modèles intégrés et d’élevage, Taconic exploite des laboratoires de services et des établissements d’élevage aux États-Unis et en Europe, entretient des relations de distribution en Asie et dispose de capacités d’expédition mondiales pour fournir des modèles animaux presque partout dans le monde.

Contact auprès des médias :

Louise Baskin, directrice principale du nouveau Pipeline de produits

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426


Taconic Biosciences Lança Primeiro e Único Modelo de Camundongo Super Imunodeficiente Sem Receptores Gama Fc Murino Residuais, para Avaliação de Terapia de Anticorpo Aprimorada

Modelos FcResolv™ NOG proporcionam dados mais claros e mais traduzíveis

RENSSELAER, NY, Oct. 24, 2022 (GLOBE NEWSWIRE) — A Taconic Biosciences, líder global no fornecimento de soluções de modelo animal para descoberta de medicamentos, lançou o portfólio FcResolv™ NOG, o primeiro e único modelo de camundongo superimunodeficiente sem receptores Fc gama murinos residuais (FcγRs) conhecidos por confundir os resultados nos estudos de terapia com base em anticorpos.

Os FcγRs murinos podem causar falsos positivos ou falsos negativos, levando a conclusões incorretas e afetar a descoberta de medicamentos. Os modelos FcResolv NOG eliminam esses receptores para maior clareza nos estudos de medicamentos com base em anticorpos, proporcionando aos investigadores maior confiança e dados mais traduzíveis, com menos estudos e menos animais. Com aplicabilidade em oncologia, imuno-oncologia e doença autoimune, os modelos FcResolv NOG são adequados para enxertos de uma ampla gama de células e tecidos humanos, incluindo enxerto simultâneo de tumor humano e humanização do sistema imunológico.

“As terapias com base em anticorpos são uma das classes de medicamentos de crescimento mais rápido, criando uma necessidade urgente de melhores ferramentas pré-clínicas para a avaliação terapêutica, como de anticorpos monoclonais, conjugados anticorpo-droga e anticorpos biespecíficos”, disse o Dr. Michael Seiler, vice-presidente de produtos comerciais da Taconic. “O portfólio FcResolv NOG da Taconic permite que pesquisadores avaliem candidatos a medicamentos como esses por si próprios, sem interferência da atividade residual do receptor Fc gama murino.”

Os modelos FcResolv NOG eliminam os falsos negativos que ocorrem quando o domínio Fc de um terapêutico com base em anticorpos interage com os FcγRs murinos, bem como os falsos positivos que resultam quando os FcγRs desencadeiam atividade imune murina residual. Eles também eliminam as etapas dispendiosas de desconvolução que normalmente são necessárias para distinguir a verdadeira eficácia do medicamento dos efeitos fora do alvo mediados pelo sistema imunológico do camundongo. Com respostas mais confiáveis, os pesquisadores podem direcionar seus investimentos em descoberta de medicamentos de forma mais estratégica e eficaz.

O portfólio do modelo FcResolv NOG tem como base o CIEA NOG mouse® superimunodeficiente. Atualmente, o portfólio inclui dois modelos:

  • FcResolv NOG, para xenoenxertos de tumores com linhagens celulares ou tumores derivados de pacientes, enxerto de outras células e tecidos humanos normais ou patológicos, e estudos de humanização do sistema imunológico
  • FcResolv hIL-15 NOG, que aceita enxertos de células NK humanas e é adequado para estudos de eficácia em terapêutica com base em anticorpos com um mecanismo de ação de citotoxicidade celular dependente de anticorpos (ADCC)

Para mais informação sobre o portfólio FcResolv NOG, visite www.Taconic.com/fcresolv. Ou ligue para 1-888-TACONIC (888-822-6642) nos EUA, +45 70 23 04 05 na Europa, ou envie email para info@taconic.com.

Sobre a Taconic Biosciences, Inc.

A Taconic Biosciences é uma líder global totalmente licenciada em serviços e modelos geneticamente modificados. Fundada em 1952, a Taconic oferece as melhores soluções/modelos de pesquisas em murinos, para que os clientes possam adquirir, customizar, criar, pré-condicionar, testar e distribuir valiosos modelos de pesquisa em todo o mundo. Especializada em modelos de camundongos e de ratos geneticamente projetados, microbioma, modelos de camundongos imuno-oncologia, e serviços de design e criação de modelos integrados, a Taconic opera laboratórios de serviços e instalações de criação nos EUA e na Europa, mantém relações com distribuidores na Ásia , e tem capacidades de entrega em nível global para oferecer modelos em quase qualquer lugar no mundo.

Contato com a Mídia:

Louise Baskin, Diretora Sênior de Pipeline de Novos Produtos

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426

Announcement from the Ministry of Health (24-10-2022)

Two patients have been diagnosed positive for COVID-19 in tests carried out today at Testing Station in the Central Region.

On the other hand, two patients who have been receiving medical treatment in hospital in the Central Region have recovered fully and have been discharged from the facility.

The total number of recovered patients has accordingly increased to 10,080 while the number of deaths stands at 103.

The total number of confirmed cases in the country to date has increased to 10,187.

 

Source: Ministry of Information Eritrea

CounterPunch.org: Ethiopia: Peace Is Impossible While TPLF Roam The Land

As Ethiopians celebrated the new year on 11 September, the TPLF (Tigray People’s Liberation Front) issued a Stance on a Peaceful Resolution of the Current Conflict. Choking on hypocrisy it states that they were, are, will one day be, prepared to “participate in a robust peace process under the auspices of the African Union (AU)”. And agree to “abide by an immediate and mutually agreed cessation of hostilities in order to create a conducive atmosphere.” Utter lies; beyond the boundaries of such meaningless words TPLF violence continued unabated.

The AU organised peace talks (8/9 October) in South Africa; invitations were sent a hall booked, hotel rooms reserved and presumably dinner reservations made. But to the surprise of nobody, the TPLF refused to engage because of “logistical issues”. As a result the fighting, killing, and destruction goes onTalks are now re-scheduled to take place in South Africa on 24 October.

The TPLF is in no position to set conditions for participation; they are a criminal organization, not a legitimate political group. They do not represent the people of Tigray, are despised throughout the country – including within Tigray; their army is in tatters, forced recruitment of children and other civilians is widespread. Far from making demands TPLF leaders should beg for forgiveness, before being hauled off to the International Criminal Court to stand trial for crimes committed during the last two years, as well as when they were in power.

Peace talks, anywhere, anytime?

In response to this latest TPLF initiated conflict, which started on 24 August, when they “broke the humanitarian truce declared by the Government in March 2022,” the Ethiopian Government issued (17 October) a Statement Concerning Defensive Measures in Northern Ethiopia. It makes clear that this is the third time in two years that the TPLF have “dragged the country into conflict” – something routinely overlooked by Western nations and media outlets; unprovoked attacks launched despite the government repeatedly proposing unconditional peace talks, “anywhere, anytime”. The official statement also relates that, astonishingly, “The PLF announced to the group of special envoys and Addis Ababa based diplomats its intentions to launch an offensive.”

Despite their complete lack of engagement in any reconciliation work, or adherence to government initiated ceasefires, the terror group claim (16 October) they “are ready to abide by an immediate cessation of hostilities [and], call on the international community to press the Ethiopian Government to come to the negotiating table.” More duplicity – the Ethiopian Government has been patiently waiting for the TPLF at said table for 18 months.

Such misleading carefully formulated statements are part of the TPLF’s Methodology of Deceit. Lies, manipulation, perversions of the truth, all are gobbled up by media and regurgitated by western governments and institutions, including some within the United Nations (UN): The head of the World Health Organisation (WHO), Dr. Tedros Ghebreyesus specifically — a former TPLF minister (who should never have been appointed to the WHO job) he has shamelessly used his platform to spread false accusations against the Ethiopian government, and present the TPLF as victims.

The World Food Program (WFP) appears to have been compromised; hundreds of WFP trucks and thousands of litres of fuel, earmarked to distribute humanitarian aid into Tigray, were “stolen” by the TPLF, and aid sold to fund their terror campaign. The “disappearance” of the trucks, according to the UN, constitutes “the primary impediment” to the aid response. In an arrogant statement, the TPLF admit the theft of 570,000 litres of fuel in August, bizarrely stating that, “It was collecting on a debt owed to them by the WFP.”

War games not peace

Since they initiated the war in November 2020 the TPLF have done nothing to suggest they want to end the conflict, on the contrary. Their lack of participation in the AU convened negotiations (8/9 October) therefore, came as no surprise, because their actions make plain that it is not peace that they want, but power.

One of the TPLF’s reasons, petty and churlish, for not attending, was that they were not consulted by the AU before invitations were sent. The terrorist’s mouthpiece, Getachew Reda said, and in a text message no less; “You don’t just expect people to show up on a certain date as if this was some kind of get-together.” Why not? If a warring faction is serious about peace, surely they will do anything to bring it about. Something as trivial as not being included in organizing the guest list, would not deter them from participating, would it?

Another complaint, closely connected to the first one, was that it was unclear what role the “international community” would play. This is TPLF code for “where are our American supporters?” We, the TPLF – a bona fide terrorist organization that started the war when we attacked the Northern Command Base of the Ethiopian army, killing unsuspecting personnel and ransacking the site for weapons – we want “our” friends at the peace table in South Africa, our US minders and facilitators. Successive American administrations (plus the UK and EU), supported the TPLF throughout their brutal 27 year reign. And, since the conflict began in November 2020, the US and Co. have, to the astonishment of shocked Ethiopians and many naive observers — who, despite decades of evidence to the contrary, still believe America to be a force for good in the world — stood side by side with the terrorists.

TPLF and western collusion

In an attempt to discredit and isolate Ethiopia, demonize the government and somehow create a confused space in which the TPLF could magically be reinstalled in Addis Ababa, a false narrative around the war, the actions of federal forces, and the distribution of humanitarian aid by UN agencies, has been constructed and propagated. A western coalition, led by the US has been employed to throw a canopy of mis/disinformation over the conflict and the actions of the TPLF, who, far from being presented as the terrorist force they are, and always have been, are somehow elevated to a position equivalent to the democratically elected government of Ethiopia.

This orchestrated propaganda campaign has been funded by the TPLF using some of the huge sums stolen during their time in office. Ann Fitz-Gerald (Director of the Balsillie School of International Affairs) states in The Frontline Voices that, “What sets this insurgency movement apart from many others is the extraordinarily large budget that the TPLF amassed during its 27 years in power, and just prior to its departure…in 2018, which left the Government of Ethiopia’s coffers empty.” In addition to funding their armed wing and its “digital insurgency of unprecedented proportions…these funds also pay for Washington-based lobby groups and law firms that have issued threatening letters to individuals – and their employers – who dare depart from the TPLF narrative.”

Given such widespread western collusion, it is plain why the TPLF want American voices at the table, and it is equally clear what role the “international community” should have in any peace talks – none whatsoever. African countries have been exploited and manipulated by such nations (US, UK, EU nations) for generations; they cannot be trusted any more than the TPLF can, i.e., not at all. The AU and fellow Africans, are very familiar with despots like the TPLF. They are more than capable of staging peace talks without interference or involvement from dried-up imperialist forces, who care not for the Ethiopian people, or indeed anyone in Sub-Sharan Africa, are driven solely by self-interest and are therefore corrupted totally.

Ethiopia under PM Abiy is seen as far too independent and democratic for American sensibilitiesSubservient regimes (aka the TPLF) lording over fragmented fractious nations of mostly uneducated poor: This is the sour American Dream for so-called developing countries in Sub-Sharan Africa, not integrated societies cooperating with neighbors, building and strengthening relationships, as part of a Pan-African movement, diverse, independent but united. A movement that is gaining ground and all power to it.

Under the TPLF, division cruelty and animosity was the order of the day, inside Ethiopia and within the Horn region, and so (in line with US foreign policy) instability was maintained. It was the TPLF that initiated the war with Eritrea in 1998, and it was PM Abiy, together with President Isaias Afwerki of Eritrea, who ended the fighting – something it is hard to imagine being well received in Washington – and created peace. At the time of the accord, President Afwerki, pointedly referring to the TPLF, said, “Hate, discrimination and conspiracy are now over. Our focus from now on should be on developing and growing together.… Now is the time to make up for the lost times.”

The TPLF has constantly revealed that it knows only violence, suppression and lies. During their time in power acts of State Terrorism were commonplace, rape and sexual violence were employed (as they have been throughout this conflict) to induce fear and human rights were totally trampled on. All we might add with the support of the “international community”; that benign self righteous force, complicit in so much suffering, that, whilst proclaiming freedom, justice and democracy, moves within the shadows sewing seeds of chaos, death and destruction, seemingly wherever it goes.

For peace talks to be positive both parties must want the conflict to end. There is no doubt that the Ethiopian government is committed to peace, likewise it is plain that the TPLF is not; they cannot be trusted, not at all. The TPLF is a deadly poison that has caused immeasurable suffering to the people of Ethiopia and the wider region for decades; in order for peace to gently settle and for social harmony to once again be established, the poison must be cut out completely. This requires the TPLF be disbanded, never again to cast their vile shadow upon the country.

 

Source: Dehai Eritrea Online

Bill & Melinda Gates Foundation Announces Additional Support to Promote Locally Led R&D; Calls for Proposals 

BRUSSELS, Oct. 24, 2022 /PRNewswire/ — The Bill & Melinda Gates Foundation today announced a series of initiatives and a call for proposals to advance locally-led innovation that supports work by scientists and researchers in developing economies. The announcement was made at the Grand Challenges Annual Meeting earlier today.

This year’s meeting focuses on lessons learned from the COVID-19 pandemic, which highlighted the need for high-impact R&D platforms, partnerships, and policies that effectively bridge the gap between innovation and equitable access. The meeting brings together researchers from around the world to share work, learn about cutting-edge advances in the health care field, and collaborate with other investigators.

“Health equity shouldn’t just be a statement of why we do this work. It should guide how we do it,” said Kedest Tesfagiorgis, deputy director of Global Partnerships & Grand Challenges at the Bill & Melinda Gates Foundation. “When we support locally led innovation, we maximize impact by bringing different kinds of knowledge and perspectives to the fore.”

As part of the Grand Challenges Global Call to Action, a 10-year initiative announced at last year’s meeting to help ensure scientists and institutions in low- and middle-income countries (LMICs) play a central role in shaping the global R&D agenda, the foundation announced two new Grand Challenges initiatives:

  • Pathogen Genomic Surveillance and Immunology in Asia : This is an invitation for proposals from investigators in South and Southeast Asia to design and pilot a genomic surveillance program or develop capacity for immunology and immune sequencing of SARS-CoV-2 to inform epidemic response. Up to $300,000 per year for up to two years will be available for each project, with potential additional funding for projects that include a focus on monoclonal antibody discovery.
  • Building Data Modeling Capacity for Gender Equality : This is an invitation for proposals from investigators in low- and middle-income countries for projects aimed at addressing disparities and gaps affecting women and girls in health. This initiative is focused on innovative approaches to modeling that advance gender equality. Each project will receive up to $500,000 over one to three years.

“Societies measure what they value, and for most of history, society hasn’t valued women. This means we’re trying to tackle global health and development challenges with missing information,” said Anita Zaidi, president of the Gender Equality division at the Bill & Melinda Gates Foundation. “It is long past time to put women and girls at the center of the data modeling that guides our solutions.”

In partnership with the Chan Zuckerberg Initiative (CZI), the foundation will also provide grants to researchers investigating and detecting emerging pathogens in LMICs. Researchers will receive up to $200,000 each for up to two years, as well as operational support and technical training from the ChanZuckerberg Biohub (CZ Biohub). This funding commitment builds on a 2018 partnership between the foundation, CZI, and the CZ Biohub that is focused on building metagenomics capacity in LMICs through a Global Grand Challenges initiative.

The 2022 Grand Challenges Annual Meeting in Brussels is hosted by Global Grand Challenges and the European Commission, and co-sponsored by Grand Challenges Canada, USAID, Wellcome, and the Bill & Melinda Gates Foundation.

The two-day event features dozens of leaders from across the global health innovation landscape, as well as Gates Foundation leadership, including Bill Gates (co-chair and trustee); Anita Zaidi; and Trevor Mundel (president, Global Health Division). The plenary sessions will be posted shortly after the meeting at grandchallenges.org/annualmeeting.

About Grand Challenges

The Bill & Melinda Gates Foundation recognizes that solving the most pressing challenges in global health and development requires more of the world’s brightest minds working on them. The Grand Challenges family of initiatives seeks to engage innovators from around the world to solve these challenges. Grand Challenges initiatives are united by their focus on fostering innovation, directing research to where it will have the most impact, and serving those most in need. To learn more, visit grandchallenges.org.

About the Bill & Melinda Gates Foundation

Guided by the belief that every life has equal value, the Bill & Melinda Gates Foundation works to help all people lead healthy, productive lives. In developing countries, it focuses on improving people’s health and giving them the chance to lift themselves out of hunger and extreme poverty. In the United States, it seeks to ensure that all people—especially those with the fewest resources—have access to the opportunities they need to succeed in school and life. Based in Seattle, Washington, the foundation is led by CEO Mark Suzman, under the direction of Co-chairs Bill Gates and Melinda French Gates and the board of trustees.

Media contact: media@gatesfoundation.org